Methyl 2-tert-butoxycarbonylaminoacrylate
[CAS 55477-80-0]

Identification

• Classification: Organic raw materials >> Carboxylic compounds and derivatives >> Carboxylic esters and their derivatives
• Name: Methyl 2-tert-butoxycarbonylaminoacrylate
• Molecular Formula: C₉H₁₅NO₄
• Molecular Weight: 201.22
• CAS Registry Number: 55477-80-0
• EC Number: 155-541-6
• SMILES: CC(C)(C)OC(=O)NC(=C)C(=O)OC

Properties

• Density: 1.1±0.1 g/cm³ Calc.^*
• Boiling point: 265.3±32.0 °C 760 mmHg (Calc.)^*
• Flash point: 114.2±25.1 °C (Calc.)^*
• Index of refraction: 1.449 (Calc.)^*

^* Calculated using Advanced Chemistry Development (ACD/Labs) Software.

Safety Data

• Hazard Symbols: GHS07 Warning
• Risk Statements: H315-H319-H335
• Safety Statements: P261-P264-P264+P265-P271-P280-P302+P352-P304+P340-P305+P351+P338-P319-P321-P332+P317-P337+P317-P362+P364-P403+P233-P405-P501

chemBlink Chemical Story

Methyl 2-(tert-butoxycarbonylamino)acrylate is a protected dehydroamino-acid derivative combining an activated double bond, a methyl ester, and a Boc-protected nitrogen. The Boc group masks the amino function during bond-forming reactions and can later be removed under acidic conditions. The electron-deficient unsaturated ester can participate in addition, reduction, substitution, and carbon-carbon bond-forming sequences. Compounds of this type are useful in amino-acid and heterocycle synthesis because chemists can introduce substituents around a future amino-acid framework while controlling when nitrogen becomes reactive. Public exact-CAS literature is mainly synthetic, so it is best described as a building block rather than assigned an independent therapeutic role.

Exact registry identity matters because free forms, salts, stereoisomers, hydrates, intermediates, and final products may have different CAS numbers even when names are closely related. Those distinctions can change molecular weight, solubility, crystallinity, analytical standards, and interpretation of published data. A reliable database therefore follows the exact substance rather than automatically transferring properties from a related form.

Functional groups provide a map of intended reactivity. Alcohols, amines, halides, esters, alkenes, and heteroaromatic rings offer different opportunities for bond formation, while the surrounding framework controls shape, electronics, and solubility. In multistep synthesis, a useful intermediate often succeeds because one position can be changed selectively while another remains available for a later operation.

Modern chemical development depends on characterization as well as synthesis. Identity, purity, stereochemistry, salt or water content, and process-related impurities may all require control. Well-characterized intermediates and reference materials remain important even when they never become final commercial products because reproducible chemistry depends on knowing exactly which substance is present.

A responsible Chemical Story distinguishes documented application from structural possibility. A familiar scaffold can suggest hypotheses, but resemblance alone does not establish a biological target, approved indication, or industrial adoption. When exact-CAS literature is limited, verified chemistry and clearly documented applications are more useful than speculation.

Practical behavior emerges from the complete molecular and material system. Structure, physical form, reaction conditions, manufacturing route, and surrounding environment can all affect performance. Connecting these details to a documented synthetic, industrial, analytical, or biological role is what turns a registry entry into a meaningful chemical story.

Exact registry identity matters because free forms, salts, stereoisomers, hydrates, intermediates, and final products may have different CAS numbers even when names are closely related. Those distinctions can change molecular weight, solubility, crystallinity, analytical standards, and interpretation of published data. A reliable database therefore follows the exact substance rather than automatically transferring properties from a related form.

Functional groups provide a map of intended reactivity. Alcohols, amines, halides, esters, alkenes, and heteroaromatic rings offer different opportunities for bond formation, while the surrounding framework controls shape, electronics, and solubility. In multistep synthesis, a useful intermediate often succeeds because one position can be changed selectively while another remains available for a later operation.

Modern chemical development depends on characterization as well as synthesis. Identity, purity, stereochemistry, salt or water content, and process-related impurities may all require control. Well-characterized intermediates and reference materials remain important even when they never become final commercial products because reproducible chemistry depends on knowing exactly which substance is present.

A responsible Chemical Story distinguishes documented application from structural possibility. A familiar scaffold can suggest hypotheses, but resemblance alone does not establish a biological target, approved indication, or industrial adoption. When exact-CAS literature is limited, verified chemistry and clearly documented applications are more useful than speculation.

References:
1. Specialist chemical catalogs. CAS 55477-80-0.
2. Literature on Boc-protected dehydroamino-acid derivatives.

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